HCID 86680527, compound → HCID 86680528, compound

HRID 1184612Notes

Reaction equation

HRID 1184612 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([O:10][C@H:11]3[CH2:40][N:14]4[CH2:15][CH2:16][N:17]([C:19](=[O:39])[CH:20]([NH:31][C:32](=[O:38])[O:33][C:34](C)(C)C)[C:21]5[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=5)[CH2:18][C@@H:13]4[CH2:12]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.C1(C2N=CC(O[C@H]3CN4CCN(C(=O)C(NC(=O)OC(C)(C)C)C5C=CC=C(C(F)(F)F)C=5)C[C@@H]4C3)=NC=2)CC1>>[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([O:10][C@H:11]3[CH2:40][N:14]4[CH2:15][CH2:16][N:17]([C:19](=[O:39])[CH:20]([NH:31][C:32](=[O:38])[O:33][CH3:34])[C:21]5[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:28])[F:29])=[CH:25][CH:26]=5)[CH2:18][C@@H:13]4[CH2:12]3)=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 86680527HCID 86680527, compoundHCID 86680529HCID 86680529, compound

Product 1

HCID 86680528HCID 86680528, compound

Procedure

The title compound was prepared according to the procedure described for Example 182, substituting the product from Example 181 for the product from Example 180. 1H NMR (300 MHz, CDCl3) δ ppm 0.81-1.03 (m, 4 H) 1.18-3.29 (m, 9 H) 3.53-3.88 (m, 5 H) 4.52-4.81 (m, 1 H) 5.18-5.40 (m, 1 H) 5.54-5.71 (m, 1 H) 6.35 (d, J=7.12 Hz, 1 H) 7.45-7.58 (m, 2 H) 7.58-7.67 (m, 2 H) 7.86-8.07 (m, 2 H); MS (ESI) m/z 520 (M+H)+.

Sources & evidence

ORD record
ord-8aaa8261d1b34e6c8af3818b8214aa16
Source dataset
uspto-grants-2014_03
Patent number
US08669255B2

Reaction notes

Loading…