HCID 86680527, compound → HCID 86680533, compound

HRID 1184615Notes

Reaction equation

[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([O:10][C@H:11]3[CH2:40][N:14]4[CH2:15][CH2:16][N:17]([C:19](=[O:39])[CH:20]([NH:31]C(=O)OC(C)(C)C)[C:21]5[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=5)[CH2:18][C@@H:13]4[CH2:12]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.C1(C2N=CC(O[C@H]3CN4CCN(C(=O)C(NC(=O)OC(C)(C)C)C5C=CC(C(F)(F)F)=CC=5)C[C@@H]4C3)=NC=2)CC1>>[NH2:31][CH:20]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:30])[F:29])[CH:22]=1)[C:19]([N:17]1[CH2:16][CH2:15][N:14]2[CH2:40][C@H:11]([O:10][C:7]3[CH:6]=[N:5][C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:9][N:8]=3)[CH2:12][C@H:13]2[CH2:18]1)=[O:39]

Participants

Reactant 2

HCID 86680527HCID 86680527, compound

HCID 86680529HCID 86680529, compound

Product 1

HCID 86680533HCID 86680533, compound

Procedure

The title compound was prepared according to the procedure described for Example 206, substituting the product from Example 180 for the product from Example 181. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.76-1.04 (m, 4 H) 1.91-4.91 (m, 12 H) 5.27-5.61 (m, 1 H) 5.65-5.96 (m, 1 H) 7.65-8.01 (m, 4 H) 8.06-8.22 (m, 2 H) 8.67-8.99 (m, 3 H) 11.27-11.94 (m, 1 H); MS (APCI) m/z 462 (M+H)+.

Sources & evidence

ORD record: ord-c12479516f0d4556a8c1e8d255b7ba89
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08669255B2

Reaction notes

Loading…