HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | methyl 2-((2S,4R)-2-(azidomethyl)-4-(5-cyclopropylpyrazin-2-yloxy)-pyrrolidin-1-yl)acetate | HCID 86680535 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-3(4H)-one | HCID 86680536 | — |
Reaction Steps
A solution of the product from Example 201B (203 mg, 0.611 mmol) in methanol (20 mL) was added to Raney®-nickel 2800, water slurry (2030 mg, 34.6 mmol) in a 50 mL pressure bottle. The mixture was stirred at ambient temperature for 16 hours under hydrogen (30 psi). The mixture was filtered and concentrated in vacuo to give the title compound. MS (ESI) m/z 275 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669255B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-2f9aef4a48054734a7cc1fe8d28e0345 |
| Source note | uspto-grants-2014_03 |