HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Erlotinib Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Erlotinib | HCID 176870 | — |
| Solvent | Isopropyl Acetate | HCID 7915 | — |
| Product | Erlotinib Hydrochloride | HCID 176871 | — |
Reaction Steps
The process of the invention may also be carried out by dissolving erlotinib free base in isopropyl acetate to form a clear solution; adding hydrochloric acid to the solution; and isolating erlotinib hydrochloride crystalline particles having mean particle size (D50) ranging from about 4 μm to 15 μm and 90 volume-% of the particles (D90) ranging from about 14 μm to 30 μm from the solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669265B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e72c50456127487fad73508f82456955 |
| Source note | uspto-grants-2014_03 |