HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → S-Phenyl thioisobutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | Isohexane ethyl acetate | HCID 21882781 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | S-Phenyl thioisobutyrate | HCID 11105960 | 72.4% |
Reaction Steps
Isobutanoyl chloride (528 μL, 5.0 mmol) in 15 mL toluene was added to a solution of triethylamine (0.70 mL, 5.0 mmol) and thiophenol (0.51 mL, 5.0 mmol) in 10 mL toluene. Reaction monitoring was accomplished by TLC: iso-hexane/ethyl acetate 25:1; Rf=0.47. Workup yielded 653 mg (72%) S-phenyl isobutanethioate 6 as pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669283B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-2bf29f90955041329b4e37fd6dce7e9b |
| Source note | uspto-grants-2014_03 |