N-bromobutanimide → 1-[4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

HRID 1184692Notes

Reaction equation

HRID 1184692 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH:2]1[CH:10]1[CH2:15][CH2:14][N:13]([C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])[CH2:12][CH2:11]1.[Br:22]N1C(=O)CCC1=O>>[Br:22][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH:2]([CH:10]3[CH2:15][CH2:14][N:13]([C:16](=[O:21])[C:17]([F:19])([F:18])[F:20])[CH2:12][CH2:11]3)[CH2:3][C:4]=2[CH:9]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 866748861-[4-(2,3-Dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 866748871-[4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanoneYield 61%

Procedure

The title compound is prepared from 1-[4-(2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone and N-bromo-succinimide following a procedure analogous to that described for Intermediate 1. Yield: 61% of theory; LC (method 2): tR=1.47 min; Mass spectrum (ESI+): m/z=378 [M+H]+.

Sources & evidence

ORD record
ord-216bbc1f2a7e422a9e154ed289d0af65
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

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