4-(Methanesulfonyl)phenylboronic acid → HCID 67973946, compound

HRID 1184706Notes

Reaction equation

HRID 1184706 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[C:15][C:16]2[C:21]([Cl:22])=[CH:20][N:19]=[C:18](Cl)[N:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:24][S:25]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)(=[O:27])=[O:26]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[C:15][C:16]2[C:21]([Cl:22])=[CH:20][N:19]=[C:18]([C:31]3[CH:32]=[CH:33][C:28]([S:25]([CH3:24])(=[O:27])=[O:26])=[CH:29][CH:30]=3)[N:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 86674892HCID 86674892, compound

Product 1

HCID 67973946HCID 67973946, compound

Procedure

The title compound is prepared from 4-(2,5-dichloro-pyrimidin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester and 4-(methanesulfonyl)phenylboronic acid following a procedure analogous to that described for Intermediate 14. LC (method 7): tR=1.58 min; Mass spectrum (ESI+): m/z=476 [M+H]+.

Sources & evidence

ORD record
ord-7ccb05e2d73f490d8ba0a5fee589f6fd
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

Loading…