HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-ethynylpiperidine-1-carboxylate → 4-(2,5-Dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-ethynylpiperidine-1-carboxylate | HCID 15550481 | — |
| Reactant | 2,5-Dichloro-4-iodopyridine | HCID 53400965 | — |
| Product | 4-(2,5-Dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86674893 | — |
Reaction Steps
The title compound is prepared from 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester and 2,5-dichloro-4-iodo-pyridine following a procedure analogous to that described for Intermediate 27. LC (method 7): tR=1.66 min; Mass spectrum (ESI+): m/z=355 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-85ae7d4bc3f7464db7fdfbfabace5395 |
| Source note | uspto-grants-2014_03 |