HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(methylsulphonyl)benzeneboronic acid → 4-[5-Chloro-2-(2-fluoro-4-methanesulfonyl-phenyl)-pyridin-4-ylethynyl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(methylsulphonyl)benzeneboronic acid | HCID 44717666 | — |
| Reactant | 4-(2,5-Dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86674893 | — |
| Product | 4-[5-Chloro-2-(2-fluoro-4-methanesulfonyl-phenyl)-pyridin-4-ylethynyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67973679 | — |
Reaction Steps
The title compound is prepared from 4-(2,5-dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester and 2-fluoro-4-(methanesulfonyl)phenylboronic acid following a procedure analogous to that described for Intermediate 14. LC (method 7): tR=1.63 min; Mass spectrum (ESI+): m/z=493 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-3428c156c56045ea81ca51218eacd373 |
| Source note | uspto-grants-2014_03 |