HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → 4-[5-Chloro-2-(2-fluoro-4-methoxycarbonyl-phenyl)-pyridin-4-ylethynyl]-piperidine-1-carboxylic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid | HCID 24824345 | — |
| Edukt | 4-(2,5-Dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86674893 | — |
| Produkt | 4-[5-Chloro-2-(2-fluoro-4-methoxycarbonyl-phenyl)-pyridin-4-ylethynyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67973741 | — |
Reaktionsschritte
The title compound is prepared from 4-(2,5-dichloro-pyridin-4-ylethynyl)-piperidine-1-carboxylic acid tert-butyl ester and 2-fluoro-4-methoxycarbonyl-phenylboronic acid following a procedure analogous to that described for Intermediate 14. LC (method 7): tR=1.76 min; Mass spectrum (ESI+): m/z=473 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08669271B2 |
| Quelldatensatz | uspto-grants-2014_03 |
| ORD ID | ord-6ed20b080b14402298bc69e1bfa9c7d4 |
| Quellennotiz | uspto-grants-2014_03 |