HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2-Ethoxy-2-oxoethyl)phenyl]boronic acid → 4-[5-(4-Carboxymethyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2-Ethoxy-2-oxoethyl)phenyl]boronic acid | HCID 45790002 | — |
| Reactant | 4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester | HCID 67973262 | — |
| Product | 4-[5-(4-Carboxymethyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid isopropyl ester | HCID 67976657 | — |
Reaction Steps
The title compound is prepared from 4-(5-bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester and 4-(ethoxycarbonylmethyl)phenyl boronic acid following a procedure analogous to that described for Intermediate 63. LC (method 5): tR=1.58 min; Mass spectrum (ESI+): m/z=424 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-23573e0ca62f4fb7b9fd37b957d66873 |
| Source note | uspto-grants-2014_03 |