(Pyrimidin-5-yl)boronic acid → HCID 67975413, compound

HRID 1184731Notes

Reaction equation

HRID 1184731 reaction equation
[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19](Br)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[N:23]1[CH:28]=[C:27](B(O)O)[CH:26]=[N:25][CH:24]=1>>[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:27]4[CH:28]=[N:23][CH:24]=[N:25][CH:26]=4)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 679732624-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester

Product 1

HCID 67975413HCID 67975413, compound

Procedure

The title compound is prepared from 4-(5-bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester and pyrimidine-5-boronic acid following a procedure analogous to that described in Example 1. LC (method 5): tR=1.49 min; Mass spectrum (ESI+): m/z=368 [M+H]+.

Sources & evidence

ORD record
ord-0d99165f4fbc48d1aee6b6970c6e1dc2
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

Loading…