Tetrabutylammonium Fluoride → HCID 67973570, compound

Participants

Reaction Steps

Tetrabutylammonium fluoride solution (1 M in tetrahydrofuran; 1.00 mL) is added to an ice cooled solution of 4-[5-(2-triisopropylsilanyl-oxazol-5-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (190 mg) in tetrahydrofuran (5 mL) and the resulting mixture is stirred for 1 h. The ice bath is removed and the reaction mixture is stirred for an additional hour at room temperature. Ethyl acetate and water are added; the organic phase is separated, dried over MgSO4, and concentrated in vacuo. The residue is recrystallised from diisopropylether. LC (method 6): tR=1.32 min; Mass spectrum (ESI+): m/z=371 [M+H]+.

Provenance & Evidence