Triethylamine → HCID 71115111, compound

Participants

Reaction Steps

Trifluoroacetic anhydride (50 mL) is added to a mixture of 4-[5-(4-carbamoyl-2-fluoro-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (50 mg) and triethylamine (100 mL) in dichloromethane (3 mL) and the reaction mixture is stirred at room temperature for 1 h. Aqueous NaHCO3 solution is added and the mixture is extracted with dichloromethane. The combined extracts are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is triturated with diethyl ether, stirred for 1 h, filtered off, and dried to give the title compound. LC (method 7): tR=1.47 min; Mass spectrum (ESI+): m/z=424 [M+H]+.

Provenance & Evidence