2-(Trifluoromethyl)pyridine-4-boronic acid → HCID 67990242, compound

HRID 1184762Notes

Reaction equation

HRID 1184762 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20](Cl)[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:24][C:25]([F:36])([F:35])[C:26]1[CH:31]=[C:30](B(O)O)[CH:29]=[CH:28][N:27]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20]([C:30]4[CH:29]=[CH:28][N:27]=[C:26]([C:25]([F:36])([F:35])[F:24])[CH:31]=4)[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 451588802-(Trifluoromethyl)pyridine-4-boronic acidHCID 866748954-(5-Chloro-2,3-dihydrofuro[2,3-c]pyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67990242HCID 67990242, compound

Procedure

The title compound is prepared from 4-(5-chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and 2-(trifluoromethyl)pyridine-4-boronic acid following a procedure analogous to that described in Example 28. LC (method 10): tR=1.82 min; Mass spectrum (ESI+): m/z=450 [M+H]+.

Sources & evidence

ORD record
ord-5664f1f161f8450c9975d53db5a771c4
Source dataset
uspto-grants-2014_03
Patent number
US08669271B2

Reaction notes

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