HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(Methylsulfonyl)methyl]phenylboronic acid → 4-[5-(4-Methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(Methylsulfonyl)methyl]phenylboronic acid | HCID 3746819 | — |
| Reactant | 4-(5-Chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid isopropyl ester | HCID 86674897 | — |
| Product | 4-[5-(4-Methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid isopropyl ester | HCID 67990216 | — |
Reaction Steps
The title compound is prepared from 4-(5-chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid isopropyl ester and [4-[(methylsulfonyl)methyl]phenyl]boronic acid following a procedure analogous to that described in Example 28. LC (method 7): tR=1.07 min; Mass spectrum (ESI+): m/z=459 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-dbf8ed4fc29f48d58888045865589254 |
| Source note | uspto-grants-2014_03 |