Imidazole → HCID 67990244, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(5-bromo-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (115 mg), imidazole (41 mg), cesium carbonate (215 mg), 1,10-phenanthroline (11 mg), and copper iodide (6 mg) in methanol (2 mL) is heated in a microwave oven to 130° C. for 45 min under an argon atmosphere. After cooling to room temperature the reaction mixture is diluted with ethyl acetate and water. The organic phase is separated, washed with brine, dried over MgSO4 and concentrated in vacuo. The residue is purified by HPLC to give the title compound. LC (method 7): tR=1.16 min; Mass spectrum (ESI+): m/z=371 [M+H]+.

Provenance & Evidence