2-Methylimidazole → HCID 67990217, compound

HRID 1184773Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20](Br)[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20]([N:26]4[CH:27]=[CH:28][N:29]=[C:25]4[CH3:24])[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 86674903HCID 86674903, compound

Product 1

HCID 67990217HCID 67990217, compound

Procedure

The title compound is prepared from 4-(5-bromo-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and 2-methyl-1H-imidazole following a procedure analogous to that described in Example 69. LC (method 7): tR=1.22 min; Mass spectrum (ESI+): m/z=385 [M+H]+.

Sources & evidence

ORD record: ord-c76ebf26619c465bb4be6171ba7bcf4c
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08669271B2

Reaction notes

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