HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluoro-4-((methylsulfonyl)methyl)phenyl)boronic acid → 4-[5-(4-Methanesulfonylmethyl-phenyl)-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluoro-4-((methylsulfonyl)methyl)phenyl)boronic acid | HCID 67973939 | — |
| Reactant | 4-(5-Chloro-2-methyl-2,3-dihydrofuro[2,3-c]pyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester | HCID 86674901 | — |
| Product | 4-[5-(4-Methanesulfonylmethyl-phenyl)-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67990270 | — |
Reaction Steps
The title compound is prepared from 4-(5-chloro-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and 2-fluoro-4-(methylsulfonylmethyl)phenylboronic acid following a procedure analogous to that described in Example 28. LC (method 6): tR=1.14 min; Mass spectrum (ESI+): m/z=505 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-809b279ac29d4f2b8d5d4822f127019c |
| Source note | uspto-grants-2014_03 |