HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[5-(4-Cyclopropanesulfonyl-piperazin-1-yl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclopropanesulfonyl chloride | HCID 2760919 | — |
| Reactant | 4-(5-Piperazin-1-yl-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 67973467 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[5-(4-Cyclopropanesulfonyl-piperazin-1-yl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67990246 | — |
Reaction Steps
The title compound is prepared by treatment of 4-(5-piperazin-1-yl-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester with cyclopropylsulfonyl chloride in dichloromethane in the presence of triethylamine. LC (method 10): tR=1.47 min; Mass spectrum (ESI+): m/z=493 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669271B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-848f19fce3f4487b9a7de2d93ced2337 |
| Source note | uspto-grants-2014_03 |