(2-Methoxyethyl)(methyl)amine → HCID 67990229, compound

Participants

Reaction Steps

To a mixture of 4-[5-(4-carboxy-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid isopropyl ester (41 mg) in N,N-dimethylformamide (1 mL) diethyl-isopropylamine (52 mL) and 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU, 32 mg) are added. After 10 min N-(2-methoxyethyl)-methylamine (12 mg) in N,N-dimethylformamide (0.5 mL) is added. The mixture is stirred for 12 h and purified by preparative HPLC (eluent water (+0.1% TFA)/MeOH) to yield the desired product. HPLC (method 12): tR=1.99 min; Mass spectrum (ESI+): m/z=481 [M+H]+.

Provenance & Evidence