Sodium Hydroxide → 2-Chlorothieno[2,3-b]pyrazine-6-carboxylic acid

Participants

Reaction Steps

To a solution of methyl 2-chlorothieno[3,2-b]pyrazine-6-carboxylate 22 (1.23 g, 5.38 mmol) in THF (10 mL) and ethanol (10 mL) was added a solution of 2N sodium hydroxide (13.45 mL, 26.9 mmol). The reaction was stirred at rt for 1 h. The reaction mixture was poured in 2N HCl solution and the resulting precipitate was collected, washed with water and dried to give crude 2-chlorothieno[3,2-b]pyrazine-6-carboxylic acid 23 (1.027 g, 89%). NMR (400 MHz, DMSO-d6) 8.18 (s, 1H), 8.90 (s, 1H).

Provenance & Evidence