HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine → N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(2-(dimethylamino)pyrimidin-5-yl)thieno[2,3-b]pyrazine-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine | HCID 16414215 | — |
| Reactant | N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(pyridin-3-yl)thieno[2,3-b]pyrazine-6-carboxamide | HCID 86680167 | — |
| Product | N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(2-(dimethylamino)pyrimidin-5-yl)thieno[2,3-b]pyrazine-6-carboxamide | HCID 54756425 | 13% |
Reaction Steps
Preparation analogous to the synthesis of 25h by using 2-dimethylamino-pyrimidine-5-boronic acid pinacol ester (1.5 eq). Purified by HPLC to give the title compound N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(2-(dimethylamino)pyrimidin-5-yl)thieno[2,3-b]pyrazine-6-carboxamide 25k (4 mg, 13%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669256B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-afd1c0c97ef847fd915dc813361b0d2d |
| Source note | uspto-grants-2014_03 |