関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-(Bromomethyl)-3-(trifluoromethyl)benzoic acid | HCID 23145893 | — |
| 生成物 | Ethyl 4-(bromomethyl)-3-(trifluoromethyl)benzoate | HCID 23073576 | 77% |
反応手順
4-(bromomethyl)-3-(trifluoromethyl)benzoic acid 35 (650 mg, 2.296 mmol) was dissolved in ethanol (30 mL). Concentrated H2SO4 (1.224 mL, 22.96 mmol) was slowly added. The resulting mixture was heated at 80° C. overnight. The reaction mixture was cooled and neutralized with saturated Na2CO3 Solution. The resulting precipitate was collected to give crude 4-bromomethyl-3-trifluoromethyl-benzoic acid ethyl ester 36 (550 mg, 77%) which was used without further purification. (m/z)=311 an 313 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08669256B2 |
|---|
| 出典データセット | uspto-grants-2014_03 |
|---|
| ORD ID | ord-d40fdc75c4be4577b970cfcdca904486 |
|---|
| 出典メモ | uspto-grants-2014_03 |
|---|
