Hydrochloric Acid → HCID 67125632, compound

Participants

Reaction Steps

To a solution of methyl 4-methyl-3-(thieno[2,3-b]pyrazine-6-carboxamido)benzoate 49 (480 mg, 1.466 mmol) in ethanol (30 mL) was added 2NaOH (7.33 mL, 14.66 mmol). The mixture was stirred overnight at rt. The mixture was acidified with 2N HCl solution and cooled on ice. the resulting precipitation was collected to give 4-methyl-3-(thieno[2,3-b]pyrazine-6-carboxamido)benzoic acid 50 (310 mg, 67%). NMR (400 MHz, DMSO-d6) 2.36 (s, 3H), 7.46 (d, J=7.8 Hz, 1H), 7.79 (dd, J=7.8 Hz and 1.6 Hz, 1H), 7.96 (d, J=1.6 Hz, 1H), 8.54 (s, 1H), 8.77 (d, J=2.3 Hz, 1H), 8.89 (d, J=2.3 Hz, 1H), 10.57 (s, 1H), 13.01 (br s, 1H). (m/z)=314 (M+H)+.

Provenance & Evidence