Triethyl phosphite → HCID 14284086, compound

Participants

Reaction Conditions

Reaction Steps

triethyl phosphite (20 mL, 19.20 g, 116 mmol) was heated to 130° C. and 2-amino-3-cyano-5-(furan-2-yl)pyrazine 1-oxide 55 (3.37 g, 13.34 mmol) was added in portions (±20 min). The reaction was stirred for 1 h, cooled down to 70° C., water (40 mL) was added and stirred for 30 min at 70° C. Cooled down with ice bad and the resulting precipitate was collected, washed with water and dried to give 3-amino-6-(furan-2-yl)pyrazine-2-carbonitrile 56 (2.46 g, 99%). NMR (400 MHz, DMSO-d6) 6.64 (m, 1H), 6.99 (d, J=3.5 Hz, 1H), 7.51 (br s, 1H), 7.80 (m, 1H), 8.70 (s, 1H). (m/z)=187 (M+H)+.

Provenance & Evidence