HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Thieno[2,3-b]pyrazine-6-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Thieno[2,3-b]pyrazine-6-carboxylic acid | HCID 7164578 | — |
| Product | Thieno[2,3-b]pyrazine-6-carbonyl chloride | HCID 86680174 | 100% |
Reaction Steps
A solution of thieno[2,3-b]pyrazine-6-carboxylic acid (400 mg, 2.220 mmol) in thionyl chloride (1.6 mL, 22.20 mmol) was heated to 80° C. for 2 h. Concentrated to dryness and coevaporated with toluene to give thieno[2,3-b]pyrazine-6-carbonyl chloride 63 (441 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669256B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-9f22d6a82e7842899db951deb787e8c2 |
| Source note | uspto-grants-2014_03 |