反应详情

To a mixture of N-(4-methyl-3-nitrophenyl)-3-(trifluoromethyl)benzamide 66 (12 g, 37.0 mmol) and palladium on activated carbon (0.438 g, 3.70 mmol) in methanol (800 mL), hydrogen (gas) was bubbled through for 2 h. Excess of Pd/C (5 g) was added and stirred for additional 2 h. Filtered over decalite and concentrated to give N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide 67 (12 g, 88%). (m/z)=295 (M+H)+.

1. customwas bubbled through for 2 h
2. additionExcess of Pd/C (5 g) was added
3. filtrationFiltered over decalite
4. concentrationconcentrated