HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184885Generated: November 1, 2026
2-Methyl-5-Nitroaniline → N-(2-methyl-5-nitrophenyl)thieno[2,3-b]pyrazine-6-carboxamide
https://huagongshe.com/reaction/1184885
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methyl-5-Nitroaniline | HCID 7444 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Thieno[2,3-b]pyrazine-6-carboxylic acid | HCID 7164578 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-methyl-5-nitrophenyl)thieno[2,3-b]pyrazine-6-carboxamide | HCID 67125678 | 92% |
Reaction Steps
A solution of thieno[2,3-b]pyrazine-6-carboxylic acid (250 mg, 1.387 mmol), HATU (633 mg, 1.665 mmol) and DIPEA (0.459 mL, 2.77 mmol) in DMF (5 mL) was stirred for 15 min. 2-methyl-5-nitroaniline (211 mg, 1.387 mmol) was added and stirred at 60° C. for 4 h. Quenched in citric acid solution and the resulting precipitate was collected to give N-(2-methyl-5-nitrophenyl)thieno[2,3-b]pyrazine-6-carboxamide 75 (400 mg, 92%). (m/z)=315 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08669256B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-4f7cadb7f3794f9da829cd6bef1f9b05 |
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| Source note | uspto-grants-2014_03 |
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