Sodium Hydroxide → 2-Oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid

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Reaction Steps

To a solution of methyl 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylate 21 (50 mg, 0.238 mmol) in methanol (3 mL) was added a solution of 2N sodium hydroxide (0.238 mL, 0.476 mmol). The reaction was stirred at rt for 2 h. Quenched with 2N HCl solution and extracted with EtOAc. Organic layer was washed with brine, dried and evaporated to give crude 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid 84 (27 mg, 57%).

Provenance & Evidence