HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184898Generated: November 1, 2026
Sodium Bicarbonate → Methyl 3-oxo-3,4-dihydrothieno[2,3-b]pyrazine-6-carboxylate
https://huagongshe.com/reaction/1184898
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl 5-(tert-butoxycarbonylamino)-4-(2-methoxy-2-oxoethylamino)thiophene-2-carboxylate | HCID 67125563 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 3-oxo-3,4-dihydrothieno[2,3-b]pyrazine-6-carboxylate | HCID 67125580 | 100% |
Reaction Steps
To a solution of 90 (0.035 mmol, 12 mg) in dioxane (0.5 mL), HCl 4N in dioxane (1.742 mmol, 436 μl) was added and the solution was heated overnight at 80° C. The reaction was neutralized with a saturated solution of NaHCO3 and extracted with CH2Cl2 (2×). The organic layer was dried with phase separator and concentrated to give methyl 3-oxo-3,4-dihydrothieno[2,3-b]pyrazine-6-carboxylate 91 (7.3 mg, 100%). NMR (400 MHz, CDCl3) 3.96 (s, 3H), 8.05 (s, 1H), 8.29 (s, 1H). (m/z)=211 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08669256B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-a4eea02b5282495d86d7c0f6f0c1aed2 |
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| Source note | uspto-grants-2014_03 |
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