HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Chlorothieno[2,3-b]pyrazine-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-chlorothieno[2,3-b]pyrazine-6-carboxylate | HCID 86680178 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Chlorothieno[2,3-b]pyrazine-6-carboxylic acid | HCID 82393952 | 100.1% |
Reaction Steps
To a solution of methyl 3-chlorothieno[2,3-b]pyrazine-6-carboxylate 92 (2.62 mmol, 600 mg) in 5 mL THF was added sodium hydroxide 2N in water (13.12 mmol, 6560 μl) and stirred at rt for 2 h. The reaction was quenched in 2N HCl extracted with CH2Cl2/methanol (9/1) (3×). Organic layers was dried and concentrated under reduced pressure to give 3-chlorothieno[2,3-b]pyrazine-6-carboxylic acid 93 (563 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669256B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-00c52eb6a4c04834841f83d62ad395a4 |
| Source note | uspto-grants-2014_03 |