反应详情

A solution of 3-chlorothieno[2,3-b]pyrazine-6-carboxylic acid 93 (0.191 mmol, 41 mg) in thionyl chloride (27.4 mmol, 2 ml, 3262 mg) was heated at 80° C. for 2 h. Reaction mixture was concentrated under reduced pressure and co-evaporated with toluene (2×) to give 3-chlorothieno[2,3-b]pyrazine-6-carbonyl chloride 94 (44 mg, 100%).

1. customReaction mixture
2. concentrationwas concentrated under reduced pressure and co-evaporated with toluene (2×)