Hydrochloric Acid → N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(2-morpholinoethylamino)thieno[2,3-b]pyrazine-6-carboxamide hydrochloride

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Reaction Steps

Compound 96e (8 mg, 0.0137 mmol) was dissolved in dioxane (0.5 mL), 4N HCl (1 eq) was added and stirred for 1 h. Evaporated to dryness to give N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(2-morpholinoethylamino)thieno[2,3-b]pyrazine-6-carboxamide hydrochloride 96f (9 mg, 100%). %). NMR (400 MHz, DMSO-d6) 1.75 (s, 6H), 2.25 (s, 3H), 3.16 (m, 2H), 3.48 (br s, 4H), 3.79 (m, 4H), 3.99 (m, 2H), 7.28 (d, J=8.6 Hz, 1H), 7.61 (m, 2H), 7.76 (m, 2H), 7.86 (d, J=2.0 Hz, 1H), 7.95 (d, J=7.8 Hz, 1H), 8.06 (s, 1H), 8.19 (s, 1H), 8.21 (d, J=5.5 Hz, 1H), 8.31 (s, 1H), 10.17 (s, 1H), 10.37 (s, 1H), 10.49 (br s, 1H).

Provenance & Evidence