HRID1185038
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
A mixture of 106a (260.0 mg, 0.56 mmol), 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-4-chloronicotinaldehyde 103b (200.0 mg, 0.56 mmol), PdCl2(dppf) (50.0 mg, 0.056 mmol), NaOAc (90.0 mg, 1.1 mmol), K3PO4 (300 mg, 1.1 mmol) in acetonitrile (30 mL) was heated at 100° C. for 3 h. The solvent was evaporated in vacuo. The residue was purified by flash column chromatography eluting with CH2Cl2/methanol (10:1) to afford 106b (120 mg, 34%) as a brown solid. LCMS: [M+H]+ 679.3
WORKUP
后处理
- customThe solvent was evaporated in vacuo
- customThe residue was purified by flash column chromatography
- washeluting with CH2Cl2/methanol (10:1)