Acetate → 5-Bromo-3-(1-ethyl-1H-pyrazol-4-ylamino)-1-methylpyrazin-2(1H)-one

Participants

Role	Name	HCID	Charge
Reactant	Acetate	HCID 175	—
Reactant	1-Ethyl-1h-pyrazol-4-amine	HCID 7018640	—
Reactant	3,5-Dibromo-1-methyl-1H-pyrazin-2-one	HCID 13062969	—
Solvent	Isopropanol	HCID 3776	—
Product	5-Bromo-3-(1-ethyl-1H-pyrazol-4-ylamino)-1-methylpyrazin-2(1H)-one	HCID 58043741	60%

Reaction Conditions

Temperature	100 °C

Reaction Steps

A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 123b (500 mg, 4.5 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.40 g, 9.0 mmol), DIPethyl acetate (3 mL), and isopropanol (50 mL). The mixture was heated at 100° C. for 2 h. It was then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to afford 123c (802 mg, 60%) as a white solid. MS-ESI: [M+H]+ 298.0

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08669251B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-aa14444c667146bfb66bdf9cfa6faed9
Source note	uspto-grants-2014_03