5-(2,2-Difluoroethyl)-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine → 5-(2,2-Difluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine

HRID 1185146Notes

Reaction equation

HRID 1185146 reaction equation
[F:1][CH:2]([F:16])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]2[N:10]=[C:11]([N+:13]([O-])=O)[CH:12]=[C:6]2[CH2:5]1.[H][H]>C(O)C.[Pd]>[F:16][CH:2]([F:1])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]2[N:10]=[C:11]([NH2:13])[CH:12]=[C:6]2[CH2:5]1

Participants

5

Reactant 2

HCID 866840025-(2,2-Difluoroethyl)-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazineHCID 178418361HCID 178418361, compound

Product 1

HCID 866840035-(2,2-Difluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amineYield 91.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 135a (370 mg, 1.59 mmol) in ethanol (20 mL) was added Pd/C (about 200 mg). The reaction was charged with hydrogen gas (via balloon) and stirred at room temperature for 2 h. After reaction was complete, the mixture was filtered through a plug of CELITE®. The filtrate was concentrated reduced pressure to afford 135b as a yellow solid (293 mg, 91%), which was used in the next step without further purification. MS-ESI: [M+H]+ 203.2

Workup

  1. customAfter reaction
  2. filtrationthe mixture was filtered through a plug of CELITE®
  3. concentrationThe filtrate was concentrated reduced pressure

Sources & evidence

ORD record
ord-5352095144e94ed68f676f29412b2440
Source dataset
uspto-grants-2014_03
Patent number
US08669251B2

Reaction notes

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