反应详情

To a solution of 148a (220 mg, 0.924 mmol) in methanol (20 mL) was added Pd/C (22 mg). The system was evacuated and refilled with H2. After stirring at room temperature for 2 h, the mixture was filtered. The filtrate was concentrated under reduced pressure to afford 148b as a yellow solid (190 mg, 98%), which was used in the next step without further purification. MS-ESI: [M+H]+ 209.1

1. customThe system was evacuated
2. additionrefilled with H2
3. filtrationthe mixture was filtered
4. concentrationThe filtrate was concentrated under reduced pressure