反应详情

A 100-mL round-bottomed flask equipped with a magnetic stirrer was charged with 150e (2.1 g, 1.0 eq., 6.8 mmol), NaBH4 (1.29 g, 5.0 eq., 34.0 mmol), and methanol (50 mL). The mixture was stirred at room temperature for 2 h and quenched with water (30 mL). It was then concentrated under reduced pressure and the residue was extracted with dichloromethane (3×50 mL). The combined organic layer was concentrated under reduced pressure to afford crude 150f, which was used in the next step without further purification. MS-ESI: [M+H]+ 311.9

1. customA 100-mL round-bottomed flask equipped with a magnetic stirrer
2. customquenched with water (30 mL)
3. concentrationIt was then concentrated under reduced pressure
4. extractionthe residue was extracted with dichloromethane (3×50 mL)
5. concentrationThe combined organic layer was concentrated under reduced pressure