HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-pyrazol-4-amine → 5-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-pyrazol-4-amine | HCID 4770990 | — |
| Reactant | 5-(Boc-amino)-thiazole-4-carboxylic acid | HCID 58182203 | — |
| Product | 5-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide | HCID 67438294 | 32% |
Reaction Steps
Following the procedures as described in Example 113, 1-methyl-1H-pyrazol-4-amine, 5-(tert-butoxycarbonylamino)thiazole-4-carboxylic acid were reacted to give 5-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide as a white solid (13 mg, 32%) over two steps. ESIMS m/z=336.1 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669361B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-80d0d4fd85a049ce998fe5bf22c53322 |
| Source note | uspto-grants-2014_03 |