1H-pyrazol-4-amine → HCID 53482221, compound

Participants

Role	Name	HCID	Charge
Reactant	1H-pyrazol-4-amine	HCID 78035	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	5-((Tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid	HCID 67438198	—
Product	HCID 53482221	HCID 53482221	78%

Reaction Steps

Following the procedures as described in Example 113, 1H-pyrazol-4-amine, 5-(tert-butoxycarbonylamino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid and HATU were reacted to give 101 as a white solid (63 mg, 78%) over two steps. 1H NMR (400 MHz, DMSO) δ 12.51 (s, 1H), 9.71 (s, 1H), 7.95 (s, 1H), 7.74 (s, 1H), 7.65-7.44 (m, 1H), 7.27 (t, J=8.4, 2H). ESIMS m/z=322.0 (M+1)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08669361B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-3850c18679e84ebbab00ad55118f0ddc
Source note	uspto-grants-2014_03