HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoropiperidine hydrochloride → 4-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoropiperidine hydrochloride | HCID 2759158 | — |
| Reactant | 5-chloro-1-methyl-4-nitro-1H-pyrazole | HCID 12344836 | — |
| Product | 4-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine | HCID 58464755 | 99% |
Reaction Steps
Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 4-fluoropiperidine hydrochloride gave 4-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine as a white solid (280 mg, 99%). 1H NMR (400 MHz, CDCl3) δ 8.02 (s, 1H), 4.86 (dtt, J=47.9, 7.1, 3.6 Hz, 1H), 3.77 (s, 3H), 3.37 (d, J=9.4 Hz, 2H), 3.20-3.12 (m, 2H), 2.16-2.06 (m, 1H), 2.07-1.92 (m, 3H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669361B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-74b7d5fbb43444ac9a557347a1b373d7 |
| Source note | uspto-grants-2014_03 |