Piperazin-2-one → HCID 58465035, compound

HRID 1185360Notes

Reaction equation

HRID 1185360 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][C:12]1=[O:17]>>[CH3:7][N:6]1[C:2]([N:14]2[CH2:15][CH2:16][NH:11][C:12](=[O:17])[CH2:13]2)=[C:3]([N+:8]([O-:10])=[O:9])[CH:4]=[N:5]1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58465035HCID 58465035, compoundYield 100%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and piperazin-2-one gave 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperazin-2-one as a white solid (166 mg, 100%). 1H NMR (400 MHz, d6-DMSO) δ 8.21 (s, 1H), 8.09 (s, 1H), 3.78 (s, 3H), 3.44-3.30 (m, 6H)

Sources & evidence

ORD record
ord-b0fa4d46b4b44e4a995959906bd96a1d
Source dataset
uspto-grants-2014_03
Patent number
US08669361B2

Reaction notes

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