HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-FLUOROPIPERIDINE HYDROCHLORIDE → 3-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-FLUOROPIPERIDINE HYDROCHLORIDE | HCID 2759156 | — |
| Reactant | 5-chloro-1-methyl-4-nitro-1H-pyrazole | HCID 12344836 | — |
| Product | 3-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine | HCID 58464981 | 97% |
Reaction Steps
Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 3-fluoropiperidine hydrochloride gave 3-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine as a yellow oil (0.27 g, 97%). 1H NMR (400 MHz, CDCl3) δ 8.02 (s, 1H), 4.88-4.71 (m, 1H), 3.79 (s, 3H), 3.47 (ddd, J=29.8, 12.8, 2.1 Hz, 1H), 3.32-3.15 (m, 2H), 3.07-2.99 (m, 1H), 2.11-1.99 (m, 2H), 1.95-1.76 (m, 1H), 1.74-1.62 (m, 1H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669361B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-93dde2c7643c4eab82d98b7e5cbc3d89 |
| Source note | uspto-grants-2014_03 |