4-Cyanopiperidine → HCID 58464865, compound

HRID 1185371Notes

Reaction equation

HRID 1185371 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)#[N:12]>>[CH3:7][N:6]1[C:2]([N:16]2[CH2:17][CH2:18][CH:13]([C:11]#[N:12])[CH2:14][CH2:15]2)=[C:3]([N+:8]([O-:10])=[O:9])[CH:4]=[N:5]1

Participants

3

Reactant 2

HCID 1382234-CyanopiperidineHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58464865HCID 58464865, compoundYield 79%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 4-cyanopiperidine gave 1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine-4-carbonitrile as an off-white solid (0.23 g, 79%). 1H NMR (400 MHz, CDCl3) δ 8.03 (s, 1H), 3.78 (s, 3H), 3.35-3.19 (m, 4H), 2.88-2.79 (m, 1H), 2.19-2.11 (m, 2H), 2.06-1.95 (m, 2H)

Sources & evidence

ORD record
ord-96790c8c81de45dab5e94076933dcb38
Source dataset
uspto-grants-2014_03
Patent number
US08669361B2

Reaction notes

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