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HRID1185377

反应详情

EQUATION

反应方程式

HRID 1185377 的结构方程式

REACTANTS

反应物

2
结构：CC(C)n1ncc([N+](=O)[O-])c1Cl
HCID58464802

未命名化合物

结构：O=C(N[C@@H]1CCCNCC1)C(F)(F)F
HCID86658411

2,2,2-Trifluoro-N-[(4R)-hexahydro-1H-azepin-4-yl]acetamide

C8H13F3N2O

PRODUCTS

生成物

1
结构：CC(C)n1ncc([N+](=O)[O-])c1N1CCC[C@@H](NC(=O)C(F)(F)F)CC1
HCID86658425

未命名化合物

收率 52%

PROCEDURE

实验过程

Reaction of 5-chloro-1-isopropyl-4-nitro-1H-pyrazole and (R)—N-(azepan-4-yl)-2,2,2-trifluoroacetamide gave (R)-2,2,2-trifluoro-N-(1-(1-isopropyl-4-nitro-1H-pyrazol-5-yl)azepan-4-yl)acetamide as a pale yellow gum (90 mg, 52%). 1H NMR (400 MHz, CDCl3) δ 8.08 (s, 1H), 6.39 (s, 1H), 4.83-4.70 (m, 1H), 4.24-4.17 (m, 1H), 3.45-3.32 (m, 1H), 3.28-3.12 (m, 3H), 2.23-2.02 (m, 2H), 2.00-1.80 (m, 4H), 1.54-1.44 (m, 6H)