1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole → 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine

HRID 1185415Notes

Reaction equation

HRID 1185415 reaction equation
[F:1][CH:2]([F:12])[CH2:3][N:4]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[N:5]1>CO>[F:1][CH:2]([F:12])[CH2:3][N:4]1[CH:8]=[C:7]([NH2:9])[CH:6]=[N:5]1

Participants

3

Reactant 1

HCID 196146471-(2,2-difluoroethyl)-4-nitro-1H-pyrazole

Product 1

HCID 195766631-(2,2-difluoroethyl)-1H-pyrazol-4-amineYield 93.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(2,2-difluoroethyl)-4-nitro-pyrazole (235 mg, 1.33 mmol) was dissolved in methanol (50 mL) and hydrogenated on H-Cube at 50° C. and 40 bar pressure to give 1-(2,2-difluoroethyl)pyrazol-4-amine (183 mg, 93%).

Sources & evidence

ORD record
ord-15c2af23e4614fbaaf85da17089f55ad
Source dataset
uspto-grants-2014_03
Patent number
US08669361B2

Reaction notes

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