Hydrochloric Acid → (S)-N-cyclopropylpyrrolidine-2-carboxamide hydrochloride

Participants

Reaction Steps

The crude (S)-2-Cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester from the preceding reaction step was dissolved in 20 ml of saturated ethanolic hydrochloric acid and stirred for 2 h. Then, the reaction mixture was diluted with 200 ml of toluene and the solvents were removed under reduced pressure. The residue was co-distilled additional 3 times with toluene and then, triturated with ether. The obtained crystalline white solid was filtered and dried. Yield: 8.2 g.

Provenance & Evidence