1,2-Dichloroethane → HCID 68598278, compound

Participants

Reaction Steps

To a solution of 146 mg of 4-((S)-3-tert-Butoxycarbonyl-2-{[4-((S)-1-carboxy-ethoxy)-7-methyl-quinoline-2-carbonyl]-amino}-propionyl)-piperazine-1-carboxylic acid ethyl ester in 1 ml of DMF, 52 mg of EDC, 34 mg of pentafluorophenol and 24 mg of NEM was added and the reaction mixture was stirred for 2 h. Then, 62 mg of (S)-Pyrrolidine-2-carboxylic acid cyclopentylamide trifluoroacetate and 20 mg of NEM in 2 ml of DMF was added. After 1 h the reaction mixture was diluted with water. After filtration through a chem Elut® cartridge by eluting with ethyl acetate the solvents were removed under reduced pressure. The isolated crude product was pure enough for the next reaction step.

Provenance & Evidence