1,2-Dichloroethane → HCID 68601559, compound

Participants

Reaction Steps

To a solution of 80 mg of 4-{(S)-3-tert-Butoxycarbonyl-2-[(4-carboxymethoxy-7-methyl-quinoline-2-carbonyl)-amino]-propionyl}-piperazine-1-carboxylic acid ethyl ester in 8 ml of DMF, 33 mg of EDC, 32 mg of pentafluorophenol and 24 mg of NEM was added and the reaction mixture was stirred for 2 h. Then, 39 mg of (S)-Pyrrolidine-2-carboxylic acid ethylamide trifluoroacetate and 20 mg of NEM in 5 ml of DMF was added. After 1 h the reaction mixture was diluted with water. After filtration through a chem Elut® cartridge by eluting with ethyl acetate the solvents were removed under reduced pressure. The isolated crude product was pure enough for the next reaction step.

Provenance & Evidence